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<p>생체재료는 면역 활성화를 유도하는 것 외에도 치료 저항성을 극복하는 데 중추적인 역할을 합니다. De Leon 등 ¹은 임상적으로 검증된 실리카 기반 생체재료(C' dot)를 최초로 개발했는데, 이 물질은 암세포의 산화 스트레스와 세포질 내 유전체 DNA(gDNA) 방출을 유발하여 cGAS-STING-IFN-γ 축을 활성화시키고 면역원성 세포 사멸을 유도합니다( 그림 1A ). 이러한 일련의 과정은 골수 세포를 M1 표현형으로 재프로그래밍하고 골수 유래 억제 세포(MDSC)를 감소시켜 궁극적으로 CD8 + T 세포 의존적인 방식으로 면역 억제를 역전시킵니다. 더욱이, C' dot 매개 선천 면역 활성화는 치료 저항성이 높은 종양에서 PD-L1 발현을 하향 조절하여 C' dot과 PD-L1 및 IL-6 차단제를 통합한 독특한 삼중 병용 요법을 가능하게 했습니다. 이 전략은 B16-GM 흑색종 모델에서 기존 면역 요법보다 우수한 생존 이점을 제공했습니다. 본 연구는 생체 재료가 STING/IL-6/PD-L1 신호 전달 축을 조절함으로써 면역 체크포인트 억제제 내성을 극복하는 진보된 패러다임을 확립했습니다. <a class="seoquake-nofollow" href="https://blacktv99.clickn.co.kr/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">블랙티비</span></a> <a class="seoquake-nofollow" href="https://blacktv88.clickn.co.kr/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> 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