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<p>DNA 앱타머 기반 GalNAc-LYTAC은 높은 화학적 안정성, 조절 가능한 구조, 그리고 면역원성 감소를 포함한 추가적인 이점을 제공합니다. 앱타머에 트리-GalNAc 단위를 부위 특이적으로 부착함으로써, 화학양론과 위치를 정밀하게 제어할 수 있어 간세포에서 막 단백질의 빠른 리소좀 분해를 유도합니다( 그림 4B ) .98 ASGPR 결합 친화도를 향상시키기 위해 연구자들은 GalNAc 잔기를 포함하는 나선형 폴리펩타이드를 설계했습니다.105 이러한 구조화된 골격은 리간드의 유연성을 감소시키고, 수용체 친화도를 증가시키며, 세포내이입을 개선합니다. RAFT 중합체 또는 DNA 스캐폴드를 사용하는 다가성 LYTAC 플랫폼은 수용체 클러스터링을 증가시키고 약물동태학적 특성을 개선하며 모듈식 설계를 가능하게 함으로써 분해 효율을 더욱 향상시킵니다. 106 예를 들어, PD-L1을 표적으로 하는 RAFT 합성 LYTAC는 맞춤형 표적화 모듈을 통해 항PD-1 치료법과 유사한 항종양 효능을 나타냈습니다. 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