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<p> </p> <p dir="ltr" style="line-height:1.38;margin-left: -0.3865979381443277pt;margin-right: -0.38659793814434745pt;margin-top:0pt;margin-bottom:0pt;"><span id="docs-internal-guid-3cff9c35-7fff-a8dc-5884-08a20ec61b82"><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(0, 0, 0); font-variant: normal; vertical-align: baseline; white-space: pre-wrap;">전이성 암 치료를 위한 PCV</span></span></p> <p dir="ltr" style="line-height:1.38;margin-left: -0.3865979381443277pt;margin-right: -0.38659793814434745pt;margin-top:0pt;margin-bottom:0pt;"><span id="docs-internal-guid-3cff9c35-7fff-a8dc-5884-08a20ec61b82"><span style="font-size: 11pt; font-family: Arial, sans-serif; color: rgb(0, 0, 0); font-variant: normal; vertical-align: baseline; white-space: pre-wrap;">고형 종양의 원격 전이 미세환경은 면역억제 및 T 세포 기능 저하에 취약합니다. 125 백신 매개 T 세포 프라이밍 및 활성화는 APC에 의한 백신 항원 흡수 및 적절한 교차 제시(cross-presentation)에 달려 있습니다. B2M 손실 또는 HLA 이형접합성 소실로 인한 MHC 클래스 I 제시 장애는 PCV 매개 효과적인 항종양 면역 반응 유도를 저해할 수 있습니다. 126 , 127 , 128 이러한 잠재적 장벽에도 불구하고, 전이성 암 환자를 대상으로 시험된 PCV는 일부 환자에서 효과적인 것으로 입증되었습니다. 50 , 129 예를 들어, 티로신 키나제 억제제에 내성이 있는 진행성 절제 불가능 </span></span></p> <div> </div> <p><a class="seoquake-nofollow" href="https://wtv248.com/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"><span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">무료야구중계</span></a> <a class="seoquake-nofollow" href="https://mukssa-news.com/" rel="nofollow noreferrer noopener" style="font-size:0;line-height:0;text-decoration:none;" target="_blank"> <span style="color:rgb(255,255,255);font-family:LexiSaebomR;line-height:2;letter-spacing:1px;text-decoration:none;">토토사이트</span></a> <a class="seoquake-nofollow" href="https://xn--910br1nf9g2g92y.com/" rel="nofollow noreferrer noopener" 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